Induction of Fetal Hemoglobin with Erythropoietin
نویسندگان
چکیده
منابع مشابه
Induction of Fetal Hemoglobin
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متن کاملepigenetic modulations on the fetal hemoglobin induction
in recent years of experience fetal hemoglobin (hbf) induction considers as novel therapeutic approach for β-thalassemia and sickle cell in therapeutic approaches. several pharmacologic agents such as hydroxyurea, azacytidine, butyrate deriviates and immunomodulator drugs like pomalidomide and lnalidomide could able to up-regulate hbf level with different molecular and epigenetic paterns (1-4)....
متن کاملTargeted therapeutic strategies for fetal hemoglobin induction.
Increased levels of fetal hemoglobin (HbF) can ameliorate the severity of the β-hemoglobin disorders, sickle cell disease (SCD) and β-thalassemia, which are major sources of morbidity and mortality worldwide. As a result, there has been a longstanding interest in developing therapeutic approaches for inducing HbF. For more than 3 decades, the majority of HbF inducers developed were based on emp...
متن کاملFetal hemoglobin induction with butyric acid: efficacy and toxicity.
Butyric acid induces fetal hemoglobin (HbF), a property of potential therapeutic advantage in patients with disorders of globin chain synthesis. We performed dose escalation studies of this compound in baboons to assess whether clinically significant increases in HbF are achievable, and to define the associated toxicities. Additionally, the effect of butyrate in combination with erythropoietin ...
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ژورنال
عنوان ژورنال: Nephron
سال: 1993
ISSN: 1660-8151,2235-3186
DOI: 10.1159/000187508